A vicious cycle of bisretinoid formation and oxidation relevant to recessive Stargardt disease
Jin Zhao, Hye Jin Kim, Keiko Ueda, Kevin Zhang, Diego Montenegro, Joshua L. Dunaief, Janet R. Sparrow
Abstract
mice. In neural retina of the mutant mice, reduced Tfrc mRNA was also an indicator of retinal iron overload. Thus iron chelation may defend retina when bisretinoid toxicity is implicated in disease processes.
Topics & Concepts
ChemistryRetinalReactive oxygen speciesDeferiproneRetinaFerritinBiochemistryBiophysicsPhotochemistryDeferoxamineBiologyNeuroscienceRetinal Diseases and TreatmentsRetinal Development and DisordersRetinoids in leukemia and cellular processes