The<i>MUC5B</i>promoter risk allele for idiopathic pulmonary fibrosis predisposes to asbestosis
Mark G. J. P. Platenburg, Ivo A. Wiertz, Joanne J. van der Vis, Bruno Crestani, Raphaël Borie, Philippe Dieudé, Caroline Kannengiesser, Jacobus A. Burgers, Jan C. Grutters, Coline H.M. van Moorsel
Abstract
Asbestosis is a fibrosing interstitial pneumonitis, which can develop following occupational asbestos exposure and a lengthy latency period [1]. Even after strict regulations on the asbestos industry, an estimated 3400 individuals worldwide died as a consequence of asbestosis in 2017 [2]. The minor allele of MUC5B rs35705950 predisposes to asbestosis, but has no effect on survival <http://bit.ly/382gPBM>
Topics & Concepts
AsbestosisAsbestosMedicinePulmonary fibrosisIdiopathic pulmonary fibrosisHypersensitivity pneumonitisAlleleFibrosisOccupational diseaseOccupational exposurePathologyLungInternal medicineEnvironmental healthBiologyGeneticsMetallurgyMaterials scienceGeneOccupational and environmental lung diseasesInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisOccupational exposure and asthma