A CRISPR-derived biosensor for the sensitive detection of transcription factors based on the target-induced inhibition of Cas12a activation
Bingzhi Li, Anqi Xia, Shilin Zhang, Tiying Suo, Yujie Ma, He Huang, Xing Zhang, Yue Chen, Xuemin Zhou
Topics & Concepts
Trans-activating crRNACRISPRActivator (genetics)Computational biologyTranscription factorBiosensorChemistryBiologyCell biologyGeneBiochemistryCas9CRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniquesRetinal Development and Disorders