Atrazine neural and reproductive toxicity
Hamid Reza Sadeghnia, Sara Shahba, Alireza Ebrahimzadeh‐Bideskan, Shabnam Mohammadi, Amir Mohammad Malvandi, Abbas Mohammadipour
Abstract
Atrazine is one of the common herbicides with an annual usage of 70,000–90,000 tons worldwide. Due to its long half-life (>60 days), atrazine persists in water and soil for long-term periods. This herbicide induces oxidative stress, inflammation, mitochondrial dysfunction and apoptosis in the exposed cells. It also passes the biological barriers, such as the blood-brain barrier and the blood-testis barrier. This review discusses, in detail, atrazine's detrimental effects on the different parts of the brain, including the cerebral cortex, hippocampus, substantia nigra, striatum, and cerebellum. Moreover, the current knowledge regarding the atrazine's effects on the reproductive system is also discussed.