Platelet-activating anti-PF4 antibodies mimic VITT antibodies in an unvaccinated patient with monoclonal gammopathy
Andreas Greinacher, Florian Länger, Linda Schönborn, Thomas Thiele, Munif Haddad, Thomas Renné, Jérôme Rollin, Yves Gruel, Theodore E. Warkentin
Abstract
<p>Transient prothrombotic disorders caused by plateletactivating antibodies against platelet factor 4 (PF4) include heparin-induced thrombocytopenia (HIT), spontaneous HIT syndrome,1 and, most recently, vaccine-induced immune thrombotic thrombocytopenia (VITT).2 Here, we identified prothrombotic, platelet-activating anti-PF4 antibodies, not associated with heparin treatment, in a patient with monoclonal gammopathy that resulted in a chronic hypercoagulability state. </p>
Topics & Concepts
AntibodyMonoclonal gammopathyMonoclonal antibodyPlateletImmunologyMedicinePlatelet factor 4MonoclonalHeparin-Induced Thrombocytopenia and ThrombosisPlatelet Disorders and TreatmentsBlood groups and transfusion