Ligand-enabled gold-catalyzed 1,2-heteroarylation of alkenes
Akash G. Tathe, Chetan C. Chintawar, Vivek W. Bhoyare, Nitin T. Patil
Abstract
By adopting the interplay between ligand-enabled Au(i)/Au(iii) catalysis and the unique π-activation mode of gold complexes, a highly coveted 1,2-heteroarylation of alkenes has been accomplished. The present ligand-enabled approach not only circumvents the requirement for strong sacrificial oxidants or photocatalysts but also operates under mild reaction conditions by utilizing simple and non-prefunctionalized aryl coupling partners.
Topics & Concepts
Ligand (biochemistry)CatalysisChemistryCombinatorial chemistryMedicinal chemistryOrganic chemistryBiochemistryReceptorCatalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms