Neutrophil Extracellular Traps in Colorectal Cancer Progression and Metastasis
Umama Khan, Sabrina Chowdhury, Md Morsaline Billah, Kazi Mohammed Didarul Islam, Henrik Thorlacius, Milladur Rahman
Abstract
Neutrophils form sticky web-like structures known as neutrophil extracellular traps (NETs) as part of innate immune response. NETs are decondensed extracellular chromatin filaments comprising nuclear and cytoplasmic proteins. NETs have been implicated in many gastrointestinal diseases including colorectal cancer (CRC). However, the regulatory mechanisms of NET formation and potential pharmacological inhibitors in the context of CRC have not been thoroughly discussed. In this review, we intend to highlight roles of NETs in CRC progression and metastasis as well as the potential of targeting NETs during colon cancer therapy.
Topics & Concepts
Neutrophil extracellular trapsColorectal cancerMetastasisContext (archaeology)ExtracellularInnate immune systemCancerCancer researchImmune systemBiologyChromatinImmunologyMedicineInflammationCell biologyGeneticsDNAPaleontologyNeutrophil, Myeloperoxidase and Oxidative MechanismsImmune cells in cancerImmune Response and Inflammation