Hypoxia drives the assembly of the multienzyme purinosome complex
Cyrielle Doigneaux, Anthony M. Pedley, Ishna N. Mistry, Monika Papayova, Stephen J. Benkovic, Ali Tavassoli
Abstract
purine biosynthesis. The findings of our study further clarify and deepen our understanding of purinosome formation by revealing that this process does not solely depend on cellular purine demand.
Topics & Concepts
Hypoxia (environmental)ChemistryBiologyCell biologyOxygenOrganic chemistryCancer, Hypoxia, and MetabolismBiochemical and Molecular ResearchRNA modifications and cancer