Unveiling the significance of inducible nitric oxide synthase: Its impact on cancer progression and clinical implications
Tong Chen
Abstract
The intricate role of inducible nitric oxide synthase (iNOS) in cancer pathophysiology has garnered significant attention, highlighting the complex interplay between tumorigenesis, immune response, and cellular metabolism. As an enzyme responsible for producing nitric oxide (NO) in response to inflammatory stimuli. iNOS is implicated in various aspects of cancer development, including DNA damage, angiogenesis, and evasion of apoptosis. This review synthesizes the current findings from both preclinical and clinical studies on iNOS across different cancer types, reflecting the variability depending on cellular context and tumor microenvironment. We explore the molecular mechanisms by which iNOS modulates cancer cell growth, survival, and metastasis, emphasizing its impact on immune surveillance and response to treatment. Additionally, the potential of targeting iNOS as a therapeutic strategy in cancer treatment is examined. By integrating insights from recent advances, this review aims to elucidate the significant role of iNOS in cancer and pave the way for novel diagnostic and therapeutic approaches. • Investigates the role of iNOS in tumor growth, survival, and metastasis. • Connects iNOS activity to DNA damage, angiogenesis, and immune evasion. • Identifies iNOS as a prognostic and predictive biomarker in cancer. • Explores targeting iNOS as a promising new therapeutic strategy for cancer treatment.