Dietary Tryptophan-Mediated Aryl Hydrocarbon Receptor Activation by the Gut Microbiota Alleviates Escherichia coli-Induced Endometritis in Mice
Caijun Zhao, Lijuan Bao, Min Qiu, Lianjun Feng, Luotong Chen, Zhuoyu Liu, Shiyu Duan, Yihong Zhao, Keyi Wu, Naisheng Zhang, Xiaoyu Hu, Yunhe Fu
Abstract
spp., damaged AhR activation, and exacerbated E. coli-induced endometritis. Supplementation with dietary Trp, AhR ligands, and L. reuteri containing AhR ligand-producing capability alleviated E. coli-induced endometritis in mice. Our results suggest an important role of microbiota-mediated AhR activation in the pathogenesis of endometritis and provide potential strategies for the intervention of infectious diseases and reproductive health by regulating the gut microbiota and metabolism.
Topics & Concepts
Aryl hydrocarbon receptorDysbiosisMicrobiologyInflammationLactobacillus reuteriBiologyEndometritisEscherichia coliGut floraChemistryImmunologyLactobacillusBiochemistryFermentationGenePregnancyTranscription factorGeneticsGut microbiota and healthTryptophan and brain disordersAsthma and respiratory diseases