Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced Corticosterone
Wen Li, Zhuo Luo, Chang‐Yu Yan, Xiaohua Wang, Zhengjie He, Shu‐Hua Ouyang, Chang Yan, Lifang Liu, Qingqing Zhou, Han-Lu Mu, Haibiao Gong, Wen‐Jun Duan, Lei Liang, Hiroshi Kurihara, Du Feng, Yi-Fang Li, Rong‐Rong He
Abstract
o models not only demonstrated the adverse effects of stress on HSV-1 infection, but also systematically investigated the underlying molecular mechanisms. These discoveries broaden our understanding of the interplay between host and viruses, and a comprehensive understanding of the role of autophagy in viral infection will provide information for future development of innovative drugs against viral infection.
Topics & Concepts
CorticosteroneAutophagyDegradation (telecommunications)Stress (linguistics)Cell biologyChemistryBiologyComputer scienceBiochemistryApoptosisTelecommunicationsHormonePhilosophyLinguisticsCytomegalovirus and herpesvirus researchMosquito-borne diseases and controlHerpesvirus Infections and Treatments