Radical Addition-Triggered Remote Migratory Isomerization of Unactivated Alkenes to Difluoromethylene-Containing Alkenes Enabled by Bimetallic Catalysis
Qiao Zhang, Qiao Zhang, Simin Wang, Qian Zhang, Qian Zhang, Tao Xiong, Qian Zhang, Qian Zhang
Abstract
A fascinating alkene remote migratory isomerization engendered by carbon radical addition to C═C bond in alkenes via bimetallic catalysis has been disclosed. A diverse array of alkenes bearing distantly incorporated the difluoromethylene (RCF2R′) functionality have been expediently obtained. The retainment of C═C bonds in products could serve as an useful synthetic platform furnishing otherwise difficult to access value-added densely functionalized RCF2R′-containing molecules. In addition, some experimental studies have been implemented to shed light on the probable mechanism.
Topics & Concepts
IsomerizationBimetallic stripAlkeneCatalysisPhotochemistryChemistryCombinatorial chemistryMigratory insertionOrganic chemistryFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsRadical Photochemical Reactions