Lower-grade gliomas surgery guided by GRPR-targeting PET/NIR dual-modality image probe: a prospective and single-arm clinical trial
Liangpeng Chen, Jingjing Zhang, Chongwei Chi, Wenqiang Che, Gehong Dong, Junmei Wang, Yanru Du, Rongxi Wang, Zhaohui Zhu, Jie Tian, Nan Ji, Xiaoyuan Chen, Deling Li
Abstract
This study has demonstrated the feasibility of the novel dual-modality imaging technique for integrated pre- and intraoperative targeted imaging via the same molecular receptor in surgeries for LGGs. The PET/NIR dual-modality probe exhibits promise for preoperative surgical planning in fluorescence-guided surgery and provides greater accuracy in guiding tumor sampling compared to 5-ALA in patients with LGGs.
Topics & Concepts
MedicineProspective cohort studyGliomaRadiologyNuclear medicineSingle CenterSampling (signal processing)Fluorescence-lifetime imaging microscopyMagnetic resonance imagingPathologySurgeryFluorescenceQuantum mechanicsComputer sciencePhysicsComputer visionFilter (signal processing)Cancer researchGlioma Diagnosis and TreatmentNanoplatforms for cancer theranosticsCancer Research and Treatments