Extrathymic <i>Aire</i> -expressing cells support maternal-fetal tolerance
Eva Mae Gillis-Buck, Haleigh S. Miller, Marina Sirota, Stephan Sanders, Vasilis Ntranos, Mark S. Anderson, James M. Gardner, Tippi C. MacKenzie
Abstract
-expressing cells (eTACs) mapped the IUGR phenotype exclusively to eTACs. Thus, we report a previously undescribed mechanism for the maintenance of maternal-fetal immune homeostasis and demonstrate that eTACs protect the conceptus from immune-mediated IUGR.
Topics & Concepts
FetusImmunologyBiologyPregnancyGeneticsReproductive System and PregnancyBirth, Development, and HealthPregnancy and preeclampsia studies