Copper catalysed oxidative cascade deamination/cyclization of vinyl azide and benzylamine for the synthesis of 2,4,6-triarylpyridines
Rana Chatterjee, Swadhapriya Bhukta, Kishore Kumar Angajala, Rambabu Dandela
Abstract
cascade deamination and annulation. Copper triflate and molecular iodine easily promoted the oxidative cyclization reaction of vinyl azide and benzylamine to access a wide variety of substituted pyridine substrates under an oxygen atmosphere. The presence of benzyl amine enables the cyclization process by providing the aryl functionality and the nitrogen source. Moreover, a broad range of substrates with good functional group tolerance, avoidance of external oxidants, excellent product yields, operational simplicity and mild conditions are the notable advantages of the present protocol.
Topics & Concepts
BenzylamineChemistryOxidative deaminationDeaminationAzideOxidative phosphorylationCascadeCombinatorial chemistryCopperOrganic chemistryMedicinal chemistryBiochemistryEnzymeChromatographyCatalytic C–H Functionalization MethodsChemical Synthesis and AnalysisSynthesis and Biological Evaluation