Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction
Robert J. Shmookler Reis, Srinivas Ayyadevara, Akshatha Ganne, Nirjal Mainali, Meenakshisundaram Balasubramaniam, Ramani Atluri, Sonu Pahal, Joseph Asante, Corey Nagel, Srikanth Vallurupalli
Abstract
<0.006). These results suggest that drug disruption of the 14-3-3G::HK1 interface blocks an early "lynchpin" adhesion, prospectively reducing aggregate accrual and progression of ADRD.
Topics & Concepts
EzetimibeChemistryNeuroscienceComputer sciencePsychologyBiochemistryCholesterol14-3-3 protein interactionsProtein Degradation and InhibitorsEnzyme Catalysis and Immobilization