Vimentin Is an Attachment Receptor for Mycoplasma pneumoniae P1 Protein
Kailan Peng, Yating Liao, Xia Li, Dongdong Zeng, Youyuan Ye, Li Chen, Zhuo Zeng, Yanhua Zeng
Abstract
Mycoplasma pneumoniae is the most common pathogen causing respiratory tract infection, and the P1 protein on its adhesion organelle plays a crucial role during the pathogenic process. A variety of experiments, including enzyme-linked immunosorbent assay (ELISA), coimmunoprecipitation, adhesion, and adhesion inhibition assay, have demonstrated that the M. pneumoniae P1 protein can interact with vimentin, that the adhesion of M. pneumoniae and recombinant P1 protein to BEAS-2B cells was affected by the expression level of vimentin.
Topics & Concepts
Mycoplasma pneumoniaeVimentinReceptorBiologyComputational biologyMedicineImmunologyGeneticsInternal medicinePneumoniaImmunohistochemistryMicrobial infections and disease researchGlycosylation and Glycoproteins ResearchImmunotherapy and Immune Responses