Olfactory receptor 78 regulates erythropoietin and cardiorespiratory responses to hypobaric hypoxia
Benjamin Wang, Yingjie Peng, Xiaoyu Su, Chongxu Zhang, Jason S. Nagati, Joseph A. Garcia, Nanduri R. Prabhakar
Abstract
In this study, we delineated a previously uncharacterized role for olfactory receptor 78 (Olfr78), a G-protein-coupled receptor in regulation of erythropoietin and cardiorespiratory responses to hypobaric hypoxia. Our results demonstrate a striking loss of cardiorespiratory adaptations accompanied by an equally striking absence of carotid body sensory nerve responses to hypobaric hypoxia in Olfr78 null mice. We further demonstrate a hitherto uncharacterized role for Olfr78 in erythropoietin activation by hypobaric hypoxia.
Topics & Concepts
ErythropoietinEndocrinologyInternal medicineHypoxia (environmental)Hypoxic ventilatory responseCarotid bodyCardiorespiratory fitnessChemistryBiologyMedicineRespiratory systemStimulationOxygenOrganic chemistryHigh Altitude and HypoxiaNeuroscience of respiration and sleepEicosanoids and Hypertension Pharmacology