Rational Design and Optimization of m<sup>6</sup>A-RNA Demethylase FTO Inhibitors as Anticancer Agents
Sarah Huff, Indrasena Reddy Kummetha, Lingzhi Zhang, Lingling Wang, William Bray, Jiekai Yin, Vanessa Kelley, Yinsheng Wang, Tariq M. Rana
Abstract
levels in a manner comparable to FTO knockdown in gastric cancer cells and regulated Wnt/PI3K-Akt signaling pathways. The oxetanyl class contains significantly improved anticancer agents with a variety of applications beyond glioblastoma.
Topics & Concepts
DemethylaseChemistryWnt signaling pathwayGene knockdownRNACancer researchPI3K/AKT/mTOR pathwayRational designMyeloid leukemiaPotencyCancerLeukemiaSmall moleculeBiochemistryPharmacologyIn vitroSignal transductionBiologyGeneEpigeneticsImmunologyGeneticsRNA modifications and cancerCancer-related gene regulationHVDC Systems and Fault Protection