BNC210, a negative allosteric modulator of the alpha 7 nicotinic acetylcholine receptor, demonstrates anxiolytic- and antidepressant-like effects in rodents
Susan O’Connor, Brad E. Sleebs, Ian P. Street, Bernard L. Flynn, Jonathan B. Baell, Carolyn Coles, Nurul H. Quazi, Dharam Paul, Etienne Poiraud, B. Huyard, Stéphanie Wagner, Emile Andriambeloson, Errol B. De Souza
Topics & Concepts
AnxiolyticAllosteric modulatorAllosteric regulationPharmacologyNicotinic acetylcholine receptorNicotinic agonistChemistryOpen fieldAgonistSedativeAntidepressantBehavioural despair testNeuroscienceReceptorPsychologyBiologyEndocrinologyBiochemistryHippocampusNicotinic Acetylcholine Receptors StudyCholinesterase and Neurodegenerative DiseasesReceptor Mechanisms and Signaling