Harnessing Visible Light for the Synthesis of <i>N</i>‐Aryl Oxazolidines: Organocatalyzed Tandem Decarboxylation‐Cyclization
Ganesh Udari, V. Murugesh, Nagaraj Sabarinathan, Balasubramanian Sridhar, Surya Prakash Singh
Abstract
Abstract Herein, we have developed an organophotocatalyzed, visible‐light mediated tandem decarboxylation‐cyclization method. The Eosin‐Y as organophotocatalyst drives photoredox tandem protocol to construct C−N, C−O, and C−C bonds in a single operation. The reaction mechanism proceeds through decarboxylation followed by amino alcohol intermediate formation from N ‐arylglycine and formaldehyde followed by cyclization with another formaldehyde delivers N ‐arylloxazolidine derivatives.
Topics & Concepts
DecarboxylationChemistryTandemCascade reactionArylAlcoholFormaldehydePhotochemistryCombinatorial chemistryStereochemistryOrganic chemistryCatalysisAlkylMaterials scienceComposite materialRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods