Comment on “Structural evidence for a dynamic metallocofactor during N <sub>2</sub> reduction by Mo-nitrogenase”
John W. Peters, Oliver Einsle, Dennis R. Dean, Serena DeBeer, Brian M. Hoffman, Patrick L. Holland, Lance C. Seefeldt
Abstract
Kang et al . (Reports, 19 June 2020, p. 1381) report a structure of the nitrogenase MoFe protein that is interpreted to indicate binding of N 2 or an N 2 -derived species to the active-site FeMo cofactor. Independent refinement of the structure and consideration of biochemical evidence do not support this claim.
Topics & Concepts
NitrogenaseReduction (mathematics)CofactorCrystallographyChemistryNitrogen fixationEnzymeBiochemistryMathematicsNitrogenGeometryOrganic chemistryMetalloenzymes and iron-sulfur proteinsAmmonia Synthesis and Nitrogen ReductionHydrogen Storage and Materials