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A reduced order model formulation for left atrium flow: an atrial fibrillation case

Caterina Balzotti, Pierfrancesco Siena, Michele Girfoglio, Giovanni Stabile, Jorge Dueñas-Pamplona, José Sierra‐Pallares, Ignacio J. Amat‐Santos, Gianluigi Rozza

2024Biomechanics and Modeling in Mechanobiology10 citationsDOIOpen Access PDF

Abstract

A data-driven reduced order model (ROM) based on a proper orthogonal decomposition-radial basis function (POD-RBF) approach is adopted in this paper for the analysis of blood flow dynamics in a patient-specific case of atrial fibrillation (AF). The full order model (FOM) is represented by incompressible Navier-Stokes equations, discretized with a finite volume (FV) approach. Both the Newtonian and the Casson's constitutive laws are employed. The aim is to build a computational tool able to efficiently and accurately reconstruct the patterns of relevant hemodynamics indices related to the stasis of the blood in a physical parametrization framework including the cardiac output in the Newtonian case and also the plasma viscosity and the hematocrit in the non-Newtonian one. Many FOM-ROM comparisons are shown to analyze the performance of our approach as regards errors and computational speed-up.

Topics & Concepts

Newtonian fluidMathematicsApplied mathematicsNon-Newtonian fluidNavier–Stokes equationsFlow (mathematics)CompressibilityMechanicsPhysicsGeometryModel Reduction and Neural NetworksCardiovascular Function and Risk FactorsFluid Dynamics and Vibration Analysis