Sex differences in solute and water handling in the human kidney: Modeling and functional implications
Rui Hu, Alicia A. McDonough, Anita T. Layton
Abstract
transport in the proximal tubules in females may also better prepare them for the fluid retention adaptations required during pregnancy and lactation. Also, kidneys play a key role in blood pressure regulation, and a popular class of anti-hypertensive medications and angiotensin converting enzymes (ACE) inhibitors have been reported to be less effective in women. Model simulations suggest that the blunted natriuretic and diuretic effects of ACE inhibition in women can be attributed, in part, to their higher distal baseline transport capacity.
Topics & Concepts
HomeostasisKidneyNephronTransporterEndocrinologyRenal functionInternal medicineDiureticRenal physiologyReabsorptionBlood pressureChemistryMedicineBiologyBiochemistryGenePregnancy and preeclampsia studiesBirth, Development, and HealthRenal function and acid-base balance