Optimization of gradient reversed phase high performance liquid chromatography analysis of acetaminophen oxidation metabolites using linear and non-linear retention model
Jana Váňová, David Maliňák, Rudolf Andrýs, Miroslav Kubát, Tomáš Mikýsek, Erika Roušarová, Kamil Musílek, Tomáš Roušar, Petr Česla
Topics & Concepts
ChemistryAcetaminophenChromatographyGlutathioneHigh-performance liquid chromatographyCysteineDerivatizationQuantitative analysis (chemistry)S9 fractionMass spectrometryCysteine metabolismConjugateBiochemistryIn vitroEnzymeMathematicsMathematical analysisMicrosomeDrug-Induced Hepatotoxicity and ProtectionPharmacogenetics and Drug MetabolismMetabolomics and Mass Spectrometry Studies