Tuning the arrangement of lamellar nanostructures: achieving the dual function of physically killing bacteria and promoting osteogenesis
Shi Mo, Kaiwei Tang, Qing Liao, Lingxia Xie, Yuzheng Wu, Guomin Wang, Qingdong Ruan, Ang Gao, Yuanliang Lv, Kaiyong Cai, Liping Tong, Zhengwei Wu, Paul K. Chu, Huaiyu Wang
Abstract
argon plasma treatment with or without pre-annealing. The two types of nanolamellae can physically kill the bacteria that come into contact with them, but the antibacterial mechanisms between the two are different. Specifically, the sharp edges of the vertically aligned nanolamellae can penetrate and damage the bacterial membrane, whereas bacteria are stuck on the tilted nanostructures and are stretched, leading to eventual destruction. The tilted nanolamellae are more desirable than the vertically aligned ones from the perspective of peri-implant bone regeneration. Our study not only reveals the role of the arrangement of nanostructures in orthopedic applications but also provides new information about different mechanisms of physical antibacterial activity.