Sphingolipids in mitochondria—from function to disease
Maryam Jamil, L. Ashley Cowart
Abstract
Sphingolipids are not only structural components of cellular membranes but also play vital roles in cell signaling and modulation of cellular processes. Within mitochondria, sphingolipids exert diverse effects on mitochondrial dynamics, energy metabolism, oxidative stress, and cell death pathways. In this review, we summarize literature addressing the crucial role of sphingolipids in mitochondria, highlighting their impact on mitochondrial dynamics, cellular bioenergetics, and important cell processes including apoptosis and mitophagy.
Topics & Concepts
MitophagySphingolipidMitochondrionCell biologyBioenergeticsBiologyOxidative stressCellOxidative phosphorylationProgrammed cell deathCell metabolismSignal transductionFunction (biology)Cell functionCell signalingApoptosisBiochemistryAutophagySphingolipid Metabolism and SignalingMitochondrial Function and PathologyAutophagy in Disease and Therapy