Direct low field J-edited diffusional proton NMR spectroscopic measurement of COVID-19 inflammatory biomarkers in human serum
Philipp Nitschke, Samantha Lodge, Drew A. Hall, Hartmut Schaefer, Manfred Spraul, Nieves Embade, Óscar Millet, Elaine Holmes, Julien Wist, Jeremy K. Nicholson
Abstract
respectively). Simplification of the sample preparation allows for data acquisition in a similar time frame to high field machines (∼4 min) and a high-throughput version with 1 min experiment time could be feasible. These data show that these newly discovered inflammatory biomarkers can be measured effectively on low field NMR instruments that do not not require housing in a complex laboratory environment, thus lowering the barrier to clinical translation of this diagnostic technology.
Topics & Concepts
SpectrometerCoronavirus disease 2019 (COVID-19)DiffusionChemistryNuclear magnetic resonanceProtonAnalytical Chemistry (journal)2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Field (mathematics)Relaxation (psychology)Proton NMRPhysicsVirologyNuclear physicsOpticsChromatographyMedicinePathologyThermodynamicsMathematicsPure mathematicsInternal medicineDiseaseOutbreakInfectious disease (medical specialty)Metabolomics and Mass Spectrometry StudiesLiver Disease Diagnosis and TreatmentInfectious Encephalopathies and Encephalitis