Development of Configurationally Labile Biaryl Reagents for Atropisomer Synthesis
Changhui Wu, Jin Yang, Xiaoyuan Zhang, Ruiqi Gao, Xiaowei Dou
Abstract
Abstract Axially chiral biaryl scaffolds are important in pharmaceuticals, natural products, and asymmetric synthesis. Atroposelective ring‐opening of configurationally labile biaryl reagents via dynamic kinetic asymmetric transformation provides a valuable approach to access axially chiral biaryl atropisomers. This review summarizes seminal contributions and recent advancements on this topic based on the use of different types of configurationally labile biaryl reagents.
Topics & Concepts
ChemistryAtropisomerReagentCombinatorial chemistryStereochemistryOrganic chemistryAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityChemical synthesis and alkaloids