Limited and Strain-Specific Transcriptional and Growth Responses to Acquisition of a Multidrug Resistance Plasmid in Genetically Diverse Escherichia coli Lineages
Steven Dunn, Laura Carrilero, Michael A. Brockhurst, Alan McNally
Abstract
Plasmids play a key role in bacterial evolution by transferring adaptive functions between lineages that often enable invasion of new niches, including driving the spread of antibiotic resistance genes. Fitness costs of plasmid acquisition arising from the disruption of cellular processes could limit the spread of multidrug resistance plasmids.
Topics & Concepts
PlasmidBiologyRegulonEscherichia coliMultiple drug resistanceOperonGeneticsAntibiotic resistanceGeneStrain (injury)MicrobiologyDrug resistanceBacteriaAnatomyAntibiotic Resistance in BacteriaEscherichia coli research studiesBacterial Genetics and Biotechnology