Prostaglandin E <sub>2</sub> Production by Brain Endothelial Cells and the Generation of Fever
Anders Blomqvist
Abstract
We recently demonstrated that prostaglandin production in brain endothelial cells is both necessary and sufficient for the generation of fever during systemic immune challenge. I here discuss this finding in light of the previous literature and point to some unresolved issues.
Topics & Concepts
BiologyImmune systemProstaglandin E2Endothelial stem cellImmunologyCell biologyEndocrinologyBiochemistryIn vitroImmune Response and InflammationInflammatory mediators and NSAID effectsImmune cells in cancer