Radiosynthesis and Bioevaluation of Ranitidine as Highly Selective Radiotracer for Peptic Ulcer Disorder Detection
M. H. Sanad, Syed Faheem Askari Rizvi, Rajendra Kumar
Abstract
Ranitidine was labeled with [125I] or [131I] with N-bromosuccinimide (NBS) and chloramine-T (Ch-T) as oxidizing agents. The substrate amount, pH of reaction medium, reaction time, and oxidizing agent were varied to find the optimum radiolabeling conditions ensuring 97% yield of [125I]iodoranitidine. Biodistribution studies demonstrate the suitability of [125I]iodoranitidine as a novel tracer to image stomach ulcer.
Topics & Concepts
ChemistryRadiosynthesisRanitidineOxidizing agentBiodistributionYield (engineering)ChloramineChloramine-TNuclear chemistryRadiochemistryChromatographyPharmacologyOrganic chemistryIn vitroNuclear medicinePositron emission tomographyBiochemistryChlorineMetallurgyMaterials scienceMedicineHelicobacter pylori-related gastroenterology studiesTuberculosis Research and EpidemiologyCancer therapeutics and mechanisms