The Impact of Silver Nanoparticles’ Size on Biofilm Eradication
Ghazal Fakeeha, Sarah AlHarbi, Sayed H. Auda, Hanan Balto
Abstract
INTRODUCTION: ] to eradicate an in vitro endodontic biofilm. METHODS: alone. Samples exposed to saline and triple antibiotic paste (TAP) acted as negative and positive control groups, respectively. After 1 and 2 weeks, samples were stained with LIVE/DEAD BacLight dye and examined under a confocal laser scanning microscope to determine the proportion of dead bacteria. RESULTS: group, all groups had significantly higher antibiofilm efficacy at 2 weeks. Both the 10 nm mixture (99.5%) and TAP (99.2%) exhibited the highest antibiofilm efficacy at 2 weeks and were not significantly different from one another (P > .05). No significant difference was noted between the 2 and 5 nm mixtures at 1 week (81% and 84%) and 2 weeks (89% and 91%). CONCLUSION: group, longer application significantly improved the antibiofilm efficacy of all tested medicaments. CLINICAL RELEVANCE: mixture revealed promising results as an intracanal medicament in the regenerative endodontic treatment protocol.