Role of KLHL3 and dietary K<sup>+</sup> in regulating KS-WNK1 expression
Mauricio Ostrosky-Frid, María Chávez‐Canales, Jinwei Zhang, Olena Andrukhova, Eduardo R. Argaiz, Fernando Lerdo-de-Tejada, Adrián Rafael Murillo‐de‐Ozores, Andrea Sánchez‐Navarro, Lorena Rojas‐Vega, Norma A. Bobadilla, Norma Vázquez, María Castañeda‐Bueno, Dario R. Alessi, Gerardo Gamba
Abstract
In this work, we demonstrated that the kidney-specific isoform of WNK1 (KS-WNK1) in the kidney is modulated by dietary K + and activity of the ubiquitin ligase protein Kelch-like protein 3. We analyzed the role of different amino acid residues of KS-WNK1 in its activity against the NaCl cotransporter and sensitivity to Kelch-like protein 3.
Topics & Concepts
Cell biologyExpression (computer science)BiologyChemistryComputer scienceProgramming languageIon Transport and Channel RegulationPancreatic function and diabetesGenetic Syndromes and Imprinting