An Elegant Four-Helical Fold in NOX and STEAP Enzymes Facilitates Electron Transport across Biomembranes—Similar Vehicle, Different Destination
Wout Oosterheert, Joana Reis, Piet Gros, Andrea Mattevi
Abstract
enzymes is featured by a de novo designed heme-binding protein, PS1. Apparently, nature and protein designers have independently converged to this fold as a versatile scaffold for heme-mediated reactions. The challenge is now to uncover the molecular mechanisms that implement the isozyme-specific regulation of the enzyme functions and develop much needed inhibitors and modulators for chemical biology and drug design studies.
Topics & Concepts
BiochemistryExtracellularEnzymeCofactorChemistryHemeIntracellularTransmembrane domainCell biologyBiologyAmino acidMetal-Catalyzed Oxygenation MechanismsNeutrophil, Myeloperoxidase and Oxidative MechanismsTrace Elements in Health