Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance
Jacqueto Zephyr, Desaboini Nageswara Rao, Sang V. Vo, M. Henes, K. Kosovrasti, Ashley N. Matthew, Adam K. Hedger, Jennifer Timm, Elise T. Chan, Akbar Ali, Neşe Kurt Yılmaz, Celia A. Schiffer
Topics & Concepts
PotencyProteaseProtease inhibitor (pharmacology)ChemistryNS3StereochemistryActive siteEnzymeCombinatorial chemistryBiochemistryBiologyIn vitroVirologyVirusAntiretroviral therapyViral loadHepatitis C virus researchHIV/AIDS drug development and treatmentBiochemical and Molecular Research