Impact of Composition and Morphology of Ketoconazole-Loaded Solid Lipid Nanoparticles on Intestinal Permeation and Gastroplus-Based Prediction Studies
Shaya Jubran Aljurbui, Afzal Hussain, Mohammad Yusuf, Mohhammad Ramzan, Obaid Afzal, Basmah Almohaywi, Sabina Yasmin, Abdulmalik Saleh Alfawaz Altamimi
Abstract
(maximum plasma concentration) and area under the curve (AUC) in rats. Thus, the present strategy could be a promising alternative to parenteral and topical delivery systems for long-term therapy against systemic and local mycoses with high patient compliance.
Topics & Concepts
IleumJejunumIn vivoPermeationEx vivoPharmacokineticsChemistryChromatographyPenetration (warfare)PharmacologyIn vitroBiochemistryBiologyBiotechnologyOperations researchEngineeringMembraneAdvancements in Transdermal Drug DeliveryEssential Oils and Antimicrobial ActivityAdvanced Drug Delivery Systems