CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells
Sougata Roy, James Sipthorp, Bidesh Mahata, Jhuma Pramanik, Marco L. Hennrich, Anne‐Claude Gavin, Steven V. Ley, Sarah A. Teichmann
Abstract
T cell function. We envisage that this methodology could be employed for other steroids to map their interactomes directly in a broad range of living cells, tissues, and organisms.
Topics & Concepts
Prostate cancerImmune systemContext (archaeology)ProteomeBiologyCancer cellCD8Computational biologyPregnenoloneChemical biologyCell biologyCancerCancer researchChemistryBioinformaticsGeneticsBiochemistryHormoneSteroidPaleontologyProstate Cancer Treatment and ResearchMass Spectrometry Techniques and ApplicationsImmunotherapy and Immune Responses