Litcius/Paper detail

Mechanistic studies on nickel-catalyzed enantioselective [3 + 2] annulation for γ-butenolide synthesis <i>via</i> C–C activation of diarylcyclopropenones

Dachang Bai, Song Liu, Junyan Chen, Yanjiang Yu, Manman Wang, Junbiao Chang, Yu Lan, Xingwei Li

2021Organic Chemistry Frontiers27 citationsDOI

Abstract

Detailed mechanistic studies on Ni-catalyzed C–C activation of cyclopropenones, and enantioselective [3 + 2] annulation with α-CF<sub>3</sub> enones or 1,2-diones toward the efficient synthesis of γ-butenolides.

Topics & Concepts

ButenolideEnantioselective synthesisAnnulationChemistryCatalysisNickelStereochemistryCombinatorial chemistryOrganic chemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsCatalytic Alkyne Reactions