Structure and function of STAC proteins: Calcium channel modulators and critical components of muscle excitation–contraction coupling
Britany Rufenach, Filip Van Petegem
Abstract
s. However, it is currently unclear whether STAC3 also forms direct interactions with RyR1, and whether this modulates RyR1 function. In this review, we discuss the 3D architecture of STAC proteins, the biochemical evidence for their interactions, the relevance of these connections for functional modulation, and their involvement in myopathy.
Topics & Concepts
Excitation–contraction couplingCalcium channelContraction (grammar)CalciumExcitationCoupling (piping)BiophysicsChemistryPhysicsMaterials scienceBiologyEndocrinologyMetallurgyOrganic chemistryQuantum mechanicsIon channel regulation and functionSignaling Pathways in DiseaseHeat shock proteins research