Therapeutic Effect of Diminazene Aceturate on Parasitic Blood Fluke Schistosoma mansoni Infection
Mariana Gontijo de Brito, Ana C. Mengarda, George Laylson da Silva Oliveira, M. Cirino, Taís C. Silva, Rosimeire Nunes de Oliveira, Silmara Marques Allegretti, Josué de Moraes
Abstract
Praziquantel is currently the only drug available to treat schistosomiasis, a disease of enormous public health significance caused by a blood fluke of the genus Schistosoma . Diminazene, a drug approved by the FDA, has been successfully used to treat diseases caused by blood protozoan parasites. In this study, we evaluated the antiparasitic properties of diminazene against Schistosoma mansoni ex vivo and in mice harboring either chronic or early S. mansoni infections.
Topics & Concepts
PraziquantelSchistosoma mansoniDiminazeneSchistosomaSchistosomiasisBiologyImmunologyHelminthiasisAntiparasitic agentPharmacologyVirologyHelminthsTrypanosomiasisParasites and Host InteractionsParasite Biology and Host InteractionsResearch on Leishmaniasis Studies