From mouth to gut: microfluidic <i>in vitro</i> simulation of human gastro-intestinal digestion and intestinal permeability
Miguel Xavier, Patrícia M. Rodrigues, Mafalda D. Neto, Maria Izabel Florindo Guedes, Víctor Calero, Lorenzo Pastrana, Catarina Gonçalves
Abstract
). Digesta from the digestion-chips were flowed through the gut-chip, demonstrating the capacity to study sample digestion and intestinal permeability in a single microfluidic platform holding great promise for use in pharmacokinetic studies.
Topics & Concepts
Digestion (alchemy)In vitroIntestinal permeabilityChemistryFood scienceChromatographyBiologyBiochemistryImmunology3D Printing in Biomedical ResearchMicrofluidic and Bio-sensing TechnologiesDiet and metabolism studies