Design, Synthesis, and <i>In Vitro</i> and <i>In Silico</i> Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents
Begüm Nurpelin Sağlık, Serkan Levent, Derya Osmani̇ye, Asaf Evrim Evren, Abdullah Burak Karaduman, Yusuf Özkay, Zafer Asım Kaplancıklı
Abstract
. Because of their various actions, it was hypothesized that the related compounds may be useful in treating AD symptoms as well as providing palliative care.
Topics & Concepts
DonepezilMonoamine oxidaseCholinesteraseChemistryAntioxidantAlzheimer's diseaseMonoamine oxidase BPharmacologyPopulationBiochemistryEnzymeMedicineDiseaseDementiaInternal medicineEnvironmental healthCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsSynthesis and biological activity