Speeding up sustainable solution-phase peptide synthesis using T3P® as a green coupling reagent: methods and challenges
Alexia Mattellone, Dario Corbisiero, Lucia Ferrazzano, Paolo Cantelmi, Giulia Martelli, Chiara Palladino, Alessandra Tolomelli, Walter Cabri
Abstract
A fast and greensolution-phase peptide synthesis (GSolPPS) via continuous protocol, addressed with propylphosphonic anhydride T3P® as coupling reagent and N -benzyloxycarbonyl-protecting group easily removed by hydrogenation is herein reported.
Topics & Concepts
ReagentCoupling (piping)Combinatorial chemistryPhase (matter)ChemistryPeptidePeptide synthesisComputer scienceOrganic chemistryMaterials scienceBiochemistryMetallurgyChemical Synthesis and AnalysisChemistry and Chemical EngineeringComputational Drug Discovery Methods