Single-cell RNA-seq dissects the intratumoral heterogeneity of triple-negative breast cancer based on gene regulatory networks
Shunheng Zhou, Yue Huang, Haizhou Liu, Xu Zhou, Mengqin Yuan, Fei Hou, Lihong Wang, Wei Jiang
Abstract
6 was ubiquitously upregulated in all subtypes, but it exerted diverse roles in each subtype through regulating different target genes. In conclusion, the construction of GRNs based on scRNA-seq data could help us to dissect the intratumoral heterogeneity and identify the critical genes of TNBC.
Topics & Concepts
Triple-negative breast cancerBiologyGene regulatory networkGeneBreast cancerCancer researchComputational biologyTranscriptomeGene expressionCancerTranscription factorGeneticsSingle-cell and spatial transcriptomicsCancer Genomics and DiagnosticsCancer Cells and Metastasis