A self-adjuvanting anti-tumor nanoliposomal vaccine based on fluorine-substituted MUC1 glycopeptide
Peijie Dong, Suying Cheng, Yudie Wang, Hang Gao, Yongmin Zhang, Tao Zhu, Peng Yu, Xin Meng
Abstract
Herein, a self-adjuvanting fluorinated MUC1-based nanoliposomal antitumor vaccine was constructed for the first time. Both the tumor-associated antigen and the mode of its presentation affect the immune response for antitumor vaccines.
Topics & Concepts
GlycopeptideImmune systemMUC1AntigenChemistryMedicineImmunologyAntibioticsBiochemistryGlycosylation and Glycoproteins ResearchCarbohydrate Chemistry and SynthesisMonoclonal and Polyclonal Antibodies Research