Radiolabeled Trastuzumab Solid Lipid Nanoparticles for Breast Cancer Cell: in Vitro and in Vivo Studies
Emre Özgenç, Merve Karpuz, Ege Arzuk, Marta González‐Álvarez, Marival Bermejo Sanz, Evren Gündoğdu, Isabel González‐Álvarez
Abstract
Tc radiolabeled) TRZ loaded SLN formulations could be promising theranostic agents based on their characterization profiles, in vitro cellular uptake and apoptosis induction capacity, and in vivo pharmacokinetic profiles.
Topics & Concepts
HaCaTSolid lipid nanoparticleIn vivoChemistryIn vitroApoptosisCytotoxicityPharmacologyCell culturePharmacokineticsSonicationBiophysicsBiochemistryDrugMedicineChromatographyBiologyBiotechnologyGeneticsNanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryProtein purification and stability