CRISPR screens identify a novel combination treatment targeting BCL-XL and WNT signaling for KRAS/BRAF-mutated colorectal cancers
Hae Rim Jung, Yumi Oh, Deukchae Na, Seoyeon Min, Jinjoo Kang, Dongjun Jang, Seungjae Shin, Ji‐Won Kim, Sang Eun Lee, Eui Man Jeong, Joon‐Yong An, Chang Ohk Sung, Won‐Suk Lee, Charles Lee, Sung‐Yup Cho
Topics & Concepts
Wnt signaling pathwayKRASCancer researchBiologyMCL1Colorectal cancerSignal transductionCancerGeneGeneticsDownregulation and upregulationCell death mechanisms and regulationCRISPR and Genetic EngineeringRNA Interference and Gene Delivery