Hydrophilic interaction liquid chromatography with mass spectrometry for the separation and identification of antisense oligonucleotides impurities and nusinersen metabolites
Zuzana Vosáhlová, Květa Kalíková, Martin Gilár, Jakub Szymarek, Maria Mazurkiewicz‐Bełdzińska, Sylwia Studzińska
Topics & Concepts
ChemistryChromatographyHydrophilic interaction chromatographyOligonucleotideMass spectrometryHigh-performance liquid chromatographyQuantitative analysis (chemistry)Liquid chromatography–mass spectrometryImpurityBiochemistryOrganic chemistryDNADNA and Nucleic Acid ChemistryRNA and protein synthesis mechanismsMicrofluidic and Capillary Electrophoresis Applications