A DNA-encoded chemical library based on chiral 4-amino-proline enables stereospecific isozyme-selective protein recognition
Sebastian Oehler, Laura Lucaroni, Francesca Migliorini, Abdullah Elsayed, Luca Prati, Sara Puglioli, Mattia Matasci, Kristina Schira, Jörg Scheuermann, Denis Yudin, Min Jia, Nenad Ban, Dave Bushnell, Roger D. Kornberg, Samuele Cazzamalli, Dario Neri, Nicholas Favalli, Gabriele Bassi
Topics & Concepts
ChemistryIsozymeStereospecificityDNAComputational biologyCombinatorial chemistryLigand (biochemistry)Target proteinGene isoformAmino acidSelectivityIn vivoStereochemistryBiochemistryEnzymeGeneGeneticsCatalysisBiologyReceptorChemical Synthesis and AnalysisClick Chemistry and ApplicationsPeptidase Inhibition and Analysis